your genes — nutrigenomics and epigenetics
Denisa Rensen
As a healthcare practitioner deeply invested in personalized medicine, I often see firsthand how individual responses to therapeutics can vary widely. Each person requires a unique approach to their health, much like how we all need different strategies to evolve our minds and adjust our mindset for thriving. Our genetic profiles play a crucial role in this process. Once you know your genetic blueprint, we can make much more precise decisions about your health. I also incorporate biomagnetic resonance assessment to add biophysics data, recognizing that we are not only genetic and epigenetic beings but also bioenergetic beings influenced by our mindset, beliefs, and experiences. Personalized medicine has many facets, and nutrigenomics is a key piece of the puzzle.
What is Nutrigenomics?
Nutrigenomics is the study of how specific nutrients and dietary components interact with your genes at a molecular level. It examines how food and nutrition affect gene expression and how genetic variations impact the nutritional environment within your body. By understanding nutrigenomics, you can tailor your diet to support your unique genetic profile, enhancing your health and preventing chronic diseases.
What is Epigenetics?
Epigenetics involves the study of heritable changes in gene expression that do not alter the underlying DNA sequence. These changes can switch genes on or off and are influenced by various factors, including diet, lifestyle, and environmental exposures. Epigenetic modifications, such as DNA methylation, can have profound effects on your health and can be influenced by your actions and environment.
Testing Your SNPs
Single Nucleotide Polymorphisms (SNPs) are variations in a single nucleotide that occur at specific positions in the genome. These variations can affect how genes function and how you respond to different nutrients. Testing your SNPs can provide valuable insights into your health and help you make informed decisions about diet, supplements, and medications.
Key SNPs to Know About
MTHFR (Methylenetetrahydrofolate Reductase): Affects folate metabolism and is crucial for DNA synthesis and repair. Mutations can lead to high homocysteine levels, increasing the risk of cardiovascular diseases.
COMT (Catechol-O-Methyltransferase): Involved in the metabolism of neurotransmitters. Variations can affect mood, stress response, and estrogen metabolism.
APOE (Apolipoprotein E): Associated with cholesterol metabolism and Alzheimer's disease risk. The APOE ε4 variant increases the risk of developing Alzheimer's.
FTO (Fat Mass and Obesity-Associated Gene): Linked to obesity and metabolic syndrome.
TNF-α (Tumor Necrosis Factor-alpha): Involved in inflammation. Certain SNPs can increase susceptibility to autoimmune diseases and chronic inflammation.
GST (Glutathione S-Transferase): Essential for detoxification. Variants can affect the body's ability to detoxify harmful substances.
VDR (Vitamin D Receptor): Affects vitamin D metabolism and bone health. Variations can influence susceptibility to osteoporosis and other health conditions.
SOD2 (Superoxide Dismutase 2): Encodes an enzyme that protects against oxidative stress. SNPs can impact the body's ability to neutralize free radicals.
ACE (Angiotensin-Converting Enzyme): Linked to blood pressure regulation and cardiovascular health.
CLOCK (Circadian Locomotor Output Cycles Kaput): Affects circadian rhythms and sleep patterns. Variations can influence susceptibility to sleep disorders and metabolic issues.
What to Do After Getting Your Results
Once you receive your genetic test results, here's how a doctor specializing in nutrigenomics might approach your case and personalize your healthcare plan:
Interpretation of Results: The doctor will analyze your genetic data, focusing on the identified SNPs that are relevant to your health concerns. This step involves understanding which of your genes are 'fast' or 'slow' and how these variations impact your overall health.
Personalized Diet Plan:
MTHFR Mutations: If you have MTHFR mutations, the doctor might recommend increasing your intake of folate-rich foods like leafy greens and avoiding synthetic folic acid.
APOE Variants: For APOE ε4 carriers, intemittent fasting, a diet low in saturated fats and rich in omega-3 fatty acids may be advised to support brain especially.
FTO Gene: Individuals with FTO variations might benefit from a diet higher in protein and fiber to help manage weight and reduce the risk of obesity.
Supplement Recommendations:
COMT Variants: Supplements such as magnesium and SAM-e might be suggested to support neurotransmitter metabolism.
GST Variants: Antioxidant supplements like N-acetylcysteine (NAC) can support detoxification processes.
VDR Variants: Vitamin D supplementation might be necessary for those with variations affecting vitamin D metabolism.
Lifestyle Modifications:
CLOCK Gene Variants: Recommendations might include improving sleep hygiene and establishing a regular sleep-wake cycle to support circadian rhythm.
Stress Management: Techniques such as mindfulness, meditation, and regular physical activity can help manage stress and reduce the impact of SNPs related to inflammation and stress response.
Medication Adjustments: Based on your genetic profile, certain medications may be more or less effective. The doctor will consider your SNPs when prescribing medications to ensure they are suitable for your genetic makeup.
Genomic Sequencing for Longevity
Studies on the genomic sequencing of supercentenarians (those aged 110 and over) have revealed genetic variants associated with longevity, particularly those involved in DNA repair and clonal hematopoiesis. These findings suggest that understanding your genetic makeup can provide insights into your potential for healthy aging and longevity.
Researchers have identified variants in genes like STK17A, which is involved in DNA damage response, and others that contribute to cellular maintenance and repair. These insights can help us understand the genetic factors that contribute to exceptional longevity and guide personalized health strategies.
Final thoughts
As a practitioner deeply invested in personalized medicine, I see every day how individual responses to different therapeutics can vary widely. Much like we all need a different approach to evolve our minds and mindset, our responses to treatments are influenced by our genetic profiles. Once you know your genetic profile, we can make much more precise decisions about your health.
In addition to genetic data, I use the biomagnetic resonance assessment to integrate biophysics data into your personalized health plan. We are not just genetic and epigenetic beings; we are also bioenergetic beings, influenced by our mindset, beliefs, and experiences. Personalized medicine encompasses many aspects, and nutrigenomics is a key piece of the puzzle.
By leveraging nutrigenomics and epigenetics, you can take proactive steps to optimize your health, mitigate genetic risks, and enhance your overall well-being. Understanding your genetic blueprint is the first step towards a personalized approach to health and longevity.
If you would like support with your gene variants data and how they relate to your health and longevity, feel free to visit our PROGRAMS.